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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) greater than 27, provided they also experience weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to stop smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and also have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a medical trial that enrolled patients without diabetes showed that patients had the average weight loss of four years old.1% rather than participants have been given placebos) within a 12- month period, while a different study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at 12 months. Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people who go through it you need to err assisting caution and permit the FDA do its job and demand some study be done so that the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on their own medications. Researchers found out that participants using this drug for the year, dropped excess weight within 4 weeks and have kept the weight off during the entire 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which can be made up of several active ingredient, that might make them more effective and safer. Combo-pilling will be the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that since right now there aren't long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise hypertension and heart rate, and mustn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients towards the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. Follow Crash Test Addict on: Twitter Facebook Linkedin Wordpress

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